A new approach for 'deep salvage' trials in advanced HIV infection.
نویسندگان
چکیده
One of the most difficult problems in HIV care today is the management of individuals infected with multidrug-resistant viruses. Well-controlled, carefully designed clinical trials have recently resulted in the approval of several new antiviral agents for the treatment of drug-resistant HIV. The design of these trials has come at the cost of the predictable emergence of drug-resistant viruses among individuals randomly assigned to receive a suboptimal revised treatment regimen. We propose here a different approach to the evaluation of drug efficacy in individuals harbouring multidrug-resistant HIV.
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عنوان ژورنال:
- AIDS
دوره 21 12 شماره
صفحات -
تاریخ انتشار 2007